News & Stories

Researchers from the Hong Kong University of Science and Technology (HKSUST) and the University of Hong Kong (HKU) recently demonstrated that the selectivity determinant of Origin Recognition Complex (ORC) for DNA binding lies in a 19-amino acid insertion helix in the Orc4 subunit, which is present in yeast but absent in human. Removal of this motif from Orc4 transforms the yeast ORC, which selects origins based on base-specific binding at defined locations, into one whose selectivity is dictated by chromatin landscape (genomic nucleosome profile), a characteristic feature shared by human ORC. Further understanding of the preferred DNA shapes and nucleosome positioning requirements will provide new insights for the plasticity of the human ORC in selecting replication initiation sites during programmed development and disease transformation, and also help identify potential targets for anti-cancer drug screening and therapy design.

Researchers of the Hong Kong University of Science and Technology (HKUST) recently uncovered a novel molecular mechanism that regulates the subcellular localizations of Arf proteins, shedding light on the mechanism underlying various inherited diseases and offering new insight to the treatment of them. 

Quantum simulations show that boson-like behaviours, so-called bosonization, emerge from an ensemble of fermions in three-dimensional systems, despite that bosons and fermions are governed by distinct quantum statistics.  In the text book of quantum mechanics,  it was introduced that bosons and fermions, two types of elementary particles that build the universe, behave in a drastically different way. For example, bosons can share the same quantum state while fermions of the same kind cannot but fill available quantum states one by one.

IAS Senior Visiting Fellow Prof. John HARDY tells us how memory loss could be an early sign of Alzheimer’s disease, which can steal more than just our memory from us.

A novel cathode design concept for lithium–sulfur battery substantially improves performance of next-generation battery used in smartphones, electric vehicles, and drones

A research team co-led by a scientist at the Hong Kong University of Science and Technology (HKUST) has developed a method to study how HIV mutates to escape the immune system in multiple patients, which could inform HIV vaccine design. HIV, which can lead to AIDS, evolves rapidly and attacks the body’s immune system. Genetic mutations in the virus enable it to evade immune responses mounted by T cells and antibodies, which makes it all the more difficult to design an effective solution. While there is no effective cure for the virus currently available, it can be controlled with medication. Now, the international research team has devised a new method from conventional statistical physics to reveal patterns of selection in HIV evolution using 14 patient data sets, providing a means to efficiently distinguishing the mutations that help the virus escape the immune system from those that are only random variations.

Prof. CHEN Kai, Associate Professor of Computer Science and Engineering, is now the brain behind what will become Hong Kong’s ‘brain’ in future – the next-generation artificial intelligence (AI) computing hub for the entire city that encompasses smart bus schedules, taxi dispatch, typhoon warning, medical diagnosis, fintech and others. 

Researchers at the Hong Kong University of Science and Technology (HKUST) have identified new therapeutic targets for Alzheimer’s disease (AD) by studying the patients’ brain with a newly-developed methodology. This novel approach also enables researchers to measure the effects of potential drugs on AD patients, opening new directions for AD research and drug development.